1e79
From Proteopedia
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BOVINE F1-ATPASE INHIBITED BY DCCD (DICYCLOHEXYLCARBODIIMIDE)
Overview
The central stalk in ATP synthase, made of gamma, delta and epsilon, subunits in the mitochondrial enzyme, is the key rotary element in the, enzyme's catalytic mechanism. The gamma subunit penetrates the catalytic, (alpha beta)(3) domain and protrudes beneath it, interacting with a ring, of c subunits in the membrane that drives rotation of the stalk during ATP, synthesis. In other crystals of F(1)-ATPase, the protrusion was, disordered, but with crystals of F(1)-ATPase inhibited with, dicyclohexylcarbodiimide, the complete structure was revealed. The delta, and epsilon subunits interact with a Rossmann fold in the gamma subunit, forming a foot. In ATP synthase, this foot interacts with the c-ring and, couples the transmembrane proton motive force to catalysis in the (alpha, beta)(3) domain.
About this Structure
1E79 is a Protein complex structure of sequences from Bos taurus with , , , and as ligands. The following page contains interesting information on the relation of 1E79 with [ATP Synthase]. Active as Transferred entry: 3.6.3.14, with EC number 3.6.1.34 Known structural/functional Sites: , , , , , and . Full crystallographic information is available from OCA.
Reference
The structure of the central stalk in bovine F(1)-ATPase at 2.4 A resolution., Gibbons C, Montgomery MG, Leslie AG, Walker JE, Nat Struct Biol. 2000 Nov;7(11):1055-61. PMID:11062563
Page seeded by OCA on Sun Feb 3 09:37:54 2008
Categories: ATP Synthase | Bos taurus | Protein complex | Transferred entry: 3.6.3.14 | Gibbons, C. | Leslie, A.G.W. | Montgomery, M.G. | Walker, J.E. | ADP | ATP | GOL | MG | SO4 | Atp phosphorylase | Atp phosphorylase (h+ transporting) | Atp synthase | Central stalk | Dccd | Dicyclohexylcarbodiimide | F1-atpase | F1fo atp synthase
