Transthyretin
From Proteopedia
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Transthyretin (TTR) is a serum carrier ot the thyroid hormone thyroxine (T4) and retinol through its association with retinol-binding protein (RBP). Many small molecules bind to TTR T4-binding site. TTR is known to be associated with amyloid diseases.
3D structures of transthyretin
2pab, 1tta, 1ttb, 1etb, 1bmz, 1f41, 1dvq, 1fh2, 1qwh, 2h4e, 2qgb, 3cbr, 3d7p, 3cfm, 3i9p, 3a4d, 3a4e, 3a4f – hTTR – human 1eta, 1ttc, 1tsh, 2trh, 2try, 1bzd, 1bze, 1fhn, 1g10, 1x7s, 2qel, 3dgd, 3did, 3kgs – hTTR (amyloidogenic mutant) 1ttr – hTTR (cardiomyapatic mutant) 1bz8, 5ttr, 1f86, 1gko, 1iii, 1iik, 1ijn, 1sok, 1soq, 1x7t, 2g3x, 2g3z, 2g4e, 2g4g, 2noy, 3bt0, 3cxf, 3djr, 3djs, 3djt, 3djz, 3dk0, 3dk2, 3do4, 3gps, 3grb, 3grg, 3i9a, 3i9i – hTTR (mutant) 1tfp – TTR – chicken 2qpf – TTR - mouse 1oo2, 1sn2 – gsTTR – gilthead seabream 1gke – rTTR – rat
TTR binary complexes
1thc, 2h1x, 2h6u – hTTR + hydroxyaurone derivative 1tlm – hTTR + milrinone 1bm7 – hTTR + flufenamic acid 1dvs, 1dvt, 1dvu, 1dvx, 1dvy, 1dvz, 1tt6, 1tz8, 2f8i, [[2fbr, [[2flm, 2g5u, 2g9k, 2gab, 2qgc, 2qgd, 2qge, 3cn0, 3cn1, 3cn2, 3cn3, 3cn4, 3esn, 3eso, 3esp, 3glz, 3gs0, 3gs4, 3gs7, 3imr, 3ims, [[3imt, [[3imu, 3imv, 3imw, 3ipb, 3ipe, 3m10 – hTTR + amyloid disease inhibitor 1u21, 3cfn, 3cfq, 3cft, 3hj0, 3nee, 3neo, 3p3r, 3p3s, [[3p3t, [[3p3u – hTTR + inhibitor 1e3f, 1e4h, 1e5a, 2b15 – hTTR + phenol derivative 2b14, 2b16 – hTTR (mutant) + phenol derivative 3kgt, 3kgu – hTTR (mutant) + genistein 3ng5 – hTTR (mutant) + epigallocatechin gallate 3nes, 3nex – hTTR (mutant) + inhibitor 1tyr – hTTR + retinoic acid 1kgi – rTTR + tetraiodotyroacetic acid 1z7t - hTTR + tetraiodotyroacetic acid 1kgj – rTTR + dibromoflavone 1zcr, 1zd6 – hTTR + anion 1y1d, 2b77, 2b9a, 3d2t, 3fc8, 3fcb – hTTR + diflunisal derivative 3b56 – hTTR + salicylic acid derivative
TTR complexes with retinol-binding potein
1rlb, 1qab – hTTR + RBP 2wqa – hTTR + RBP + oleic acid 3bsz – hTTR + RBP + antibody
TTR complexes with thyroxine
2rox, 1ict – hTTR + T4 3ozk – hTTR (mutant) + T4 1tha, 2roy – hTTR + T4 derivative 1ie4 – rTTR + T4 1sn0 – gsTTR + T4 1sn5 – gsTTR + T4 derivative
