Glutathione peroxidase

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Glutathione peroxidase (GPX) reduces lipid hydroperoxides to alcohols and free hydrogen peroxide to water. Thus, GPX protects the organism from oxidative damage. There are several isozymes of GPX. Eight isozymes have been found in human. GPX1 is found in the cytoplasm and reduces hydrogen peroxide. GPX2 is intestinal and extracellular. GPX3 is abundant in plasma. GPX4 substrate is lipid hydroxyperoxide.

Contents

GPX1

2f8a – hGPX1 (mutant) – human

3e0u – GPX1 – Trypanosoma cruzi

GPX2

2he3 – hGPX2 (mutant)

GPX3

2r37 – hGPX3 (mutant) 3cmi – GPX3 – yeast

GPX4

2gs3, 2obi – hGPX4 (mutant)

GPX5

[[2i3y – hGPX5

2p5q, 2p5r – GPX5 – poplar

GPX7

2p31 – hGPX7

GPX8

3cyn – hGPX8

GPX

1gp1 – GPX + amino-selenino-propionic acid – bovine

2v1m – SmGPX – Schistosoma mansoni

2wgr – SmGPX (mutant)

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Michal Harel

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