Shiga toxin

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Shiga Toxin Type 2 (Stx2)

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Introduction

Shiga Toxins are a family of AB5 toxins which cause dysentery in humans. They are primarily secreted by Shiga toxin-encoding Escherichia coli (STEC), notably by the 0157:H7 strain.[1]

Structure

Shiga Toxin consists consists of an AB5 hexamer.[2] The 5 subunit B pentamer interacts with a single A subunit via a C-terminal helix and 4 stranded beta-sheet.[2] The B subunit is necessary for binding to eukaryotic cell surface, where it is then endocytosed and proteolytically cleaved into two active A subunits and a B subunit. On the A subunit Tyr77, Tyr114, Glu167, Arg170, and Trp203 are all essential in glycosidic activity.[3]

Proteopedia Page Contributors and Editors (what is this?)

Max Evoy-Mount, Michal Harel, Alexander Berchansky

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