1qj8
From Proteopedia
|
CRYSTAL STRUCTURE OF THE OUTER MEMBRANE PROTEIN OMPX FROM ESCHERICHIA COLI
Overview
BACKGROUND: The integral outer membrane protein X (OmpX) from Escherichia, coli belongs to a family of highly conserved bacterial proteins that, promote bacterial adhesion to and entry into mammalian cells. Moreover, these proteins have a role in the resistance against attack by the human, complement system. Here we present the first crystal structure of a member, of this family. RESULTS: The crystal structure of OmpX from E. coli was, determined at 1.9 A resolution using multiple isomorphous replacement., OmpX consists of an eight-stranded antiparallel all-next-neighbor beta, barrel. The structure shows two girdles of aromatic amino acid residues, and a ribbon of nonpolar residues that attach to the membrane interior., The core of the barrel consists of an extended hydrogen-bonding ... [(full description)]
About this Structure
1QJ8 is a [Single protein] structure of sequence from [Escherichia coli] with C8E and PCL as [ligands]. Structure known Active Sites: PC1 and PC2. Full crystallographic information is available from [OCA].
Reference
The structure of the outer membrane protein OmpX from Escherichia coli reveals possible mechanisms of virulence., Vogt J, Schulz GE, Structure. 1999 Oct 15;7(10):1301-9. PMID:10545325
Page seeded by OCA on Tue Oct 30 12:32:19 2007
