3t6p

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Template:STRUCTURE 3t6p

IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization

Template:ABSTRACT PUBMED 22021857

About this Structure

3t6p is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Dueber EC, Schoeffler AJ, Lingel A, Elliott JM, Fedorova AV, Giannetti AM, Zobel K, Maurer B, Varfolomeev E, Wu P, Wallweber HJ, Hymowitz SG, Deshayes K, Vucic D, Fairbrother WJ. Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination. Science. 2011 Oct 21;334(6054):376-80. PMID:22021857 doi:10.1126/science.1207862

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