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spinqualitylabelsall models PDB ID 2zta Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2zta, resolution 1.80Å ()
Non-Standard Residues:
Structural annotation: Resources: UniProt : P03069
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 GCN4 - The Leucine Zipper 1.1 Structure 1.2 Binding 1.2.1 The Leucine Zipper 1.2.2 Binding with DNA 1.3 Function 2 See Also 3 Reference

GCN4 - The Leucine Zipper

Blah blah information about leucine zipper GCN4.

spinqualitylabelsall models PDB ID 1ysa Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1ysa, resolution 2.90Å ()
Structural annotation: Resources: CATH : 1Ysac00, 1Ysad00 InterPro : Ipr011616, Ipr004827 Pfam : PF00170 SCOP : d1ysac_, d1ysad_ UniProt : P03069
Functional annotation: Cellular component: nucleus Biological process: positive regulation of gene-specific transcription involved in unfolded protein response amino acid biosynthetic process regulation of transcription, DNA-dependent transcription regulation of transcription from RNA polymerase II promoter Molecular function: protein dimerization activity transcription factor activity DNA binding sequence-specific DNA binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Structure

GCN4 (PDB 2zta by itself, 1ysa bound to DNA) is a eukaryotic transcription factor first isolated from Saccharomyces cerevisiae, also known as Baker's Yeast. CITE CITE CITE It is composed of two identical 52 residue alpha helix chains that grouped together to form a dimer. The dimer binds through interlocking leucine amino acids in the C terminal ends, while pinching in on the major groove of DNA in the N terminal end. The X-ray structure of the 33-residue polypeptide corresponding to the leucine zipper of GCN4 was determined by Peter Kim and Thomas Alber^[1].

Binding

The Leucine Zipper

Binding with DNA

Function

See Also

2zta 1ysa

Reference

1. ↑ Voet, Donald; Voet, Judith G.; Pratt, Charlotte W. Fundamentals of Biochemistry: Life at the Molecular Level. 3rd Ed. Hoboken, NJ: Wiley, 2008.