Cyclin
From Proteopedia
Cyclin (CYC) activate CYC-dependent kinase (CDK) thus acting in the control of the cell cycle. The CYC name derives from the fact that their concentration varies during the cell cycle. Among the CYCs, CYCA are active in the S phase, CYCD regulate the transition from G1 to S.
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3D Structures of Cyclin
Update November 2011
CYCA2
3my5, 2wpa, 2wxv, 2wih, 2wip, 3f5x, 3eoc, 3eid, 3ej1, 3dog, 3ddp, 3ddq, 3bht, 2v22, 2uue, 2i40, 2bkz, 2c5n, 2c5o, 2c5v, 2c5x, 2c5y, 2bpm, 2c4g, 1fvv – hCYCA2 +CDK2+inhibitor - human
3bhu, 3bhv, 2uzd, 2uzb, 2uze, 2uzl, 2uzn, 2uzo, 2iw6, 2iw8, 2iw9, 2g9x, 1oi9, 1oiu, 1oiy, 1ogu, 1p5e, 1pkd, 1h1p, 1h1q, 1h1r, 1h1s - hCYCA2 +CDK2 T160P+inhibitor
1fin - hCYCA2 +CDK2
1vyw - hCYCA2 C-terminal + hCDK2
1jst - hCYCA2 +CDK2 T160P
1h24, 1h25, 1h26, 1h27, 1h28, 1gy3 - hCYCA2 +CDK2 T160P+peptide
2cjm - hCYCA2 +CDK2 T160P Y15P
2cch - hCYCA2 +CDK2 T160P+ATP analog
2cci - hCYCA2 +CDK2 T160P+CDC homolog
2wma, 2wmb, 2x1n, 2wev, 2wfy, 2whb, 1okv, 1okw, 1ol1, 1ol2, 1urc, 1qmz - hCYCA2 +CDK2+peptide
1jsu - hCYCA2 +CDK2 (mutant)+P27
3qhr, 3khw - CYCA2 + P33 protein kinase + CDK2 peptide – mouse
CYCA3
1vin – CYCA3 - bovine
1e9h – hCYCA3 +CDK2 T160P+inhibitor
CYCB1
2b9r – hCYCB1 (mutant)
2jgz - hCYCB1 +CDK2
CYCD
2w96, 2w99, 2w9f, 2w9z - hCYCD1 +CDK4 (mutant)
3g33 – hCYCD3 +CDK4
CYCE
1w98 – hCYCE1 +CDK2 T160P
CYCH
CYCK
2i53 – hCYCK N-terminal
CYCT
3blh - hCYCT1 +CDK9
3blq - hCYCT1 +CDK9+ATP
3lq5 – hCYCT1 (mutant)+CDK9
3blr - hCYCT1 +CDK9+inhibitor
3my1 - hCYCT1 (mutant)+CDK9+inhibitor
3mi9, 3mia - hCYCT1 +CDK9+protein TAT
2pk2 - hCYCT1/protein TAT
2w2h - CYCT1 +protein TAT + RNA – horse
2ivx – hCYCT2 (mutant)
CYC
2pk9 – yCYC PHO80 +CDK PHO85 – yeast
2pmi - yCYC PHO80 +CDK PHO85+ATPgS
Viral CYC
2euf, 2f2c, 2xo2, 1jow – V-CYC viral+hCDK6 – Herpesvirus
1bu2 – V-CYC
1xo2 - V-CYC + hCDK6 + inhibitor
1g3n - V-CYC viral+hCDK6+CDK6 inhibitor
1f5q - V-CYC g viral+hCDK2
