User:Udayan Shevade/Sandbox1
From Proteopedia
Contents |
SV40 Large T Antigen
Introduction
The SV40 large T antigen is a multifunctional regulatory protein encoded by Simian Virus 40. It belongs to the AAA+ family of helicases [1]. The protein is responsible for initiation of DNA replication, regulation of transcription and alteration of the host cell cycle to promote infectivity. Large T antigen is an early gene product of SV40 and is translated via differential mRNA splicing.
Structure
T-antigen consists of an N-terminal J domain, a central origin-binding domain, and a C-terminal helicase domain [1].
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| 1svm, resolution 1.94Å () | |||||||||
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| Ligands: | , , | ||||||||
| Related: | 1svl, 1svo | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Helicase
The monomer of the helicase contains a AAA+ domain. Each monomer binds and hydrolyzes an ATP in the presence of magnesium and drives an overall conformational change in the hexamer.
