1w6s
From Proteopedia
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THE HIGH RESOLUTION STRUCTURE OF METHANOL DEHYDROGENASE FROM METHYLOBACTERIUM EXTORQUENS
Overview
The crystal structure of methanol dehydrogenase (MDH) from, Methylobacterium extorquens has been refined without stereochemical, restraints at a resolution of 1.2 A. The high-resolution data have defined, the conformation of the tricyclic pyrroloquinoline quinone (PQQ) cofactor, ring as entirely planar. The detailed definition of the active-site, geometry has shown many features that are similar to the, quinohaemo-protein alcohol dehydrogenases from Comamonas testosteroni and, Pseudomonas putida, both of which possess MDH-like and cytochrome c-like, domains. Conserved features between the two types of PQQ-containing enzyme, suggest a common pathway for electron transfer between MDH and its, physiological electron acceptor cytochrome cL. A pathway for proton, transfer from the active site to the bulk solvent is also suggested.
About this Structure
1W6S is a Protein complex structure of sequences from Methylobacterium extorquens with , and as ligands. Active as Alcohol dehydrogenase (acceptor), with EC number 1.1.99.8 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The atomic resolution structure of methanol dehydrogenase from Methylobacterium extorquens., Williams PA, Coates L, Mohammed F, Gill R, Erskine PT, Coker A, Wood SP, Anthony C, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Jan;61(Pt 1):75-9. Epub 2004 Dec, 17. PMID:15608378
Page seeded by OCA on Sun Feb 3 10:20:01 2008
Categories: Alcohol dehydrogenase (acceptor) | Methylobacterium extorquens | Protein complex | Anthony, C. | Coates, L. | Cooper, J.B. | Erskine, P.T. | Gill, R. | Mohammed, F. | Williams, P.A. | Wood, S.P. | CA | GOL | PQQ | Anisotropic | Calcium-binding | Electron transfer | Methanol utilization | Oxidoreductase | Pqq
