Plasminogen activator

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Plasminogen activator (PLA) is a serine protease which converts plasminogen to plasmin. It includes Tissue PLA (TPA) which is involved in breakdown of blood clots and urokinase-type PLA Urokinase. TPA structure contains heavy and light chains (HC, LC). PLA is inhibited by PLA inhibitor 1 and 2.

1 3D structures of plasminogen activator
2 Tissue plasminogen activator

3D structures of plasminogen activator

1a5i – PLA residues 213-477 + EGR-CMK – Vampire bat
1bqy – PLA – Pit viper

Tissue plasminogen activator

1a5h – hTPA HC+LC + benzamidine – human
1rtf - hTPA HC+LC
1tpg – hTPA F1-G - NMR
1bda – hTPA catalytic domain (mutant) + EGR-CMK
1pk2 – hTPA kringle 2 domain + 6-aminohexanoic acid – NMR
1tpk - hTPA kringle 2 domain
1tpm, 1tpn - hTPA fibrin-binding domain – NMR