Plasminogen activator inhibitor

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Template:STRUCTURE 1c5g

Plasminogen activator inhibitor (PAI) is a serine protease inhibitor. PAI-1 inhibits tissue plasminogen activator and urokinase. PAI-2 is secreted by the placenta and is present during pregnancy. PAI-3 inhibits enzymes in blood coagulation.

Contents

3D Structures of plasminogen activator inhibitor

PAI-1

1c5g, 1lj5 - hPAI-1 – human
1b3k, 1db2, 1dvm, 1dvn, 3cvm, 3eox, 3q02, 3q03, 3r4l - hPAI-1 (mutant)
1a7c, 9pai – hPAI-1 (mutant) + polypeptide
1oc0 - hPAI-1 (mutant) + vitronectin
3pb1 - hPAI-1 (mutant) + urokinase (mutant)
3lw2 – PAI-1 - mouse

PAI-2

1by7 - hPAI-2 (mutant)
1jrr, 2arq, 2arr - hPAI-2 (mutant) + polypeptide

PAI-3

2ol2 – hPAI-3
2hi9 - hPAI-3 residues 25-387
1lq8, 3dy0 – hPAI-3 cleaved

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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