Brittany deRonde/Sandbox 1

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One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.

HIV Tat is a human immunodeficiency virus (HIV) gene that regulates transcription of HIV dsRNA and is often simply referred to as Tat. Tat, which stands for trans-activator of transcription, contains 86 amino acid residues in its sequence.

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Green and Lowenstein, and Frankel and Pabo independently published studies in Cell in 1988 that showed that Tat had the ability to cross cellular membranes and initiate transcription of HIV dsRNA

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Brittany deRonde, Coralie Backlund

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