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From Proteopedia
proteopedia linkproteopedia link Cholesteryl Ester Transfer Protein (CETP)
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| 2obd, resolution 2.10Å ()
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| Ligands:
| , , , , , , ,
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| Gene:
| CETP (Homo sapiens)
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| Resources:
| FirstGlance, OCA, RCSB, PDBsum
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| Coordinates:
| save as pdb, mmCIF, xml
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Introduction
Cholesteryl Ester Transfer Protein is a plasma glycoprotein which is implicated in the transport of cholesteryl esters from the atheroprotective high-density lipoproteins (HDL) to the atherogenic lower-density lipoproteins (LDL). The cristal structure of CETP at 2,2-Å resolution in complex with four bound lipid molecules shows a long tunnel which traverses the core of the molecule and has two distinct large openings allowing lipid access. This tunnel is plugged by an amphiphilic phosphatidylcholine at each end.
