Sandbox 215

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Contents 1 Cholesteryl Ester Transfer Protein (CETP) 2 Introduction 3 Role of CETP 4 Structure 5 CETP inhibition 6 References

Cholesteryl Ester Transfer Protein (CETP)

spinqualitylabelsall models PDB ID 2obd Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2obd, resolution 2.10Å ()
Ligands:	, , , , , , ,
Gene:	CETP (Homo sapiens)
Structural annotation: Resources: InterPro : Ipr001124 Pfam : PF02886, PF01273 UniProt : Q53YZ1
Functional annotation: Molecular function: lipid binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Introduction

Cholesteryl Ester Transfer Protein is a plasma glycoprotein which is implicated in the transport of cholesteryl esters from the atheroprotective high-density lipoproteins (HDL) to the atherogenic lower-density lipoproteins (LDL). The cristal structure of CETP at 2,2-Å resolution in complex with four bound lipid molecules shows a long tunnel which traverses the core of the molecule and has two distinct large openings allowing lipid access. This tunnel is plugged by an amphiphilic phosphatidylcholine at each end.

Role of CETP

Structure

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CETP inhibition

References