2xra

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Image:2xra.png

Template:STRUCTURE 2xra

crystal structure of the HK20 Fab in complex with a gp41 mimetic 5- Helix

Template:ABSTRACT PUBMED 21124990

About this Structure

2xra is a 3 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA.

Reference

  • Sabin C, Corti D, Buzon V, Seaman MS, Lutje Hulsik D, Hinz A, Vanzetta F, Agatic G, Silacci C, Mainetti L, Scarlatti G, Sallusto F, Weiss R, Lanzavecchia A, Weissenhorn W. Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41. PLoS Pathog. 2010 Nov 18;6(11):e1001195. PMID:21124990 doi:10.1371/journal.ppat.1001195
  • Luftig MA, Mattu M, Di Giovine P, Geleziunas R, Hrin R, Barbato G, Bianchi E, Miller MD, Pessi A, Carfi A. Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody. Nat Struct Mol Biol. 2006 Aug;13(8):740-7. Epub 2006 Jul 23. PMID:16862157 doi:10.1038/nsmb1127

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