Acetylcholinesterase Inhibitor Pharmacokinetics

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Acetylcholinesterase Inhibitor Pharmacokinetics
Parameter	Donepezil	Tacrine	Rivastigmine	Galantamine
T_max (hr)	3.6	1.5	.3	1.2
C_max (ng/ml)	6.5	15.7	29.3	42.6
Bioavailability (%)	100	17	36	100
Protein Binding (%)	96	55	40	10
T_1/2 (hr)	70	3	5	7.3
AUC (ng/ml/hr)	380	80.4	191	427
IC₅₀ (nM)	6.7 (Rat)	450 (Human)	1535 (Human)	1995 (Rat)
Dosage (mg)	5	160	6	8
Metabolism	Hepatic (CYP2D6 & CYP3A4) & AChE	Hepatic (CYP1A2) & AChE	AChE	Hepatic (CYP3A4 & CYP2D6) & AChE

For Pharmacokinetic Data References, see: References

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