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spinqualitylabelsall models Human ankyrin-1 D34 region complex with chloride and bromide ions 1n11 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

ANKRD2 belongs to the conserved muscle ankyrin repeat protein (MARP) family.Also known as Arpp or stretch responsive muscle ANKRD2 gene contains 9 exons and spans about 12 kb. The 5-prime flanking region contains a TATA box and binding motifs for the muscle-specific transcription factors MYOD and for NF-kappa-B.

Kemp et.al cloned mouse Ankrd2 and obtained a partial human ANKRD2 cDNA. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. Northern blot and PCR analyses detected expression of mouse Ankrd2 only in tissues containing striated muscle. In situ hybridization of mouse embryos showed that Ankrd2 expression was restricted to the myotome of somites at day 9.5. At later developmental stages, Ankrd2 expression was stronger in outer back muscles than intercostal muscles, and it was not expressed in heart.

3D Structures of Ankyrin

Ankyrin

1n11 – hANK-1 D34 region – human
2yqf, 2yvi – hANK-1 death domain – NMR
3f59 – hANK-1 spectrin-binding domain
3kbt, 3kbu - hANK-1 residues 911-1068 + spectrin β chain
3so8 – hANK-A residues 149-310
1n0q, 1n0r, 2bkg, 2qyj – dANK repeats – designed
1svx – dANK + maltose-binding protein
3noc, 3nog – dANK + acriflavine resistance protein B
2aja – ANK – Legionella pneumophila
3hra – ANK – Enterococus faecalis
3q9u, 3q9n – ANK + COA-binding protein – Escherichia coli

Gankyrin

1uoh, 1qym – hGANK
1tr4 – hGANK – NMR
2dvw, 2dwz, 3aji – GANK + 26S protease regulatory subunit 6B C terminal - mouse