Factor inhibiting HIF

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Template:STRUCTURE 1mzf

1 3D Structures of factor inhibiting HIF
- 1.1 FIH complex with small molecule
- 1.2 FIH complex with polypeptide

3D Structures of factor inhibiting HIF

1mze, 1h2n, 1iz3 – hFIH1 – human

FIH complex with small molecule

1yci – hFIH1 + phenylalanine derivative
2w0x - hFIH1 + pyridine derivative
2cgn – hFIH1 + succinate
2cgo – hFIH1 + fumarate
1mzf, 2wa3, 2wa4, 2yc0, 2yde – hFIH1 + oxoglutarate derivative
3kcx, 3kcy, 3od4 - hFIH1 + quinol derivative

FIH complex with polypeptide

1h2k, 1h2l, 1h2m – hFIH1 + HIF transactivation domain peptide
2ilm, 3d8c - hFIH1 (mutant) + HIF peptide + α-ketoglutarate
3p3n, 3p3p - hFIH1 + Notch 1 peptide
2xum - hFIH1 (mutant) + Asp-substrate peptide + oxoglutarate derivative
2y0i - hFIH1 + tankyrase 2 peptide