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2x9d

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Image:2x9d.png

Template:STRUCTURE 2x9d

Tet repressor (class D) in complex with iso-7-chlortetracycline

Template:ABSTRACT PUBMED 21699184

About this Structure

2x9d is a 1 chain structure with sequence from Escherichia coli. This structure supersedes the now removed PDB entry 1du7. Full crystallographic information is available from OCA.

Reference

  • Volkers G, Petruschka L, Hinrichs W. Recognition of drug degradation products by target proteins: isotetracycline binding to Tet repressor. J Med Chem. 2011 Jul 28;54(14):5108-15. Epub 2011 Jul 1. PMID:21699184 doi:10.1021/jm200332e
  • Hinrichs W, Kisker C, Duvel M, Muller A, Tovar K, Hillen W, Saenger W. Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance. Science. 1994 Apr 15;264(5157):418-20. PMID:8153629

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