Structural genomics

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Structural genomics is a large, international project, started around 2001, that aims to determine new protein structures using high throughput techniques, and to develop faster techniques for X-ray crystallography and NMR.

Protein sequences are often selected for structure determination because they represent a sequence-family for which no member's structure is known. These are called target sequences. Determination of the structure of such a sequence enables the structures of other sequence-related proteins to be predicted by homology modeling. Many of the institutions participating in structural genomics report their target sequences, and their progress in determining their structures, in the Target Database for Structural Biology.

References

↑ Jenney FE Jr, Adams MW. The impact of extremophiles on structural genomics (and vice versa). Extremophiles. 2008 Jan;12(1):39-50. Epub 2007 Jun 13. PMID:17563834 doi:10.1007/s00792-007-0087-9