Chromodomain-helicase-DNA-binding protein

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Template:STRUCTURE 2b2u

Chromodomain-helicase-DNA-binding protein (CHD) remodel chromatin and histone deacylation thus affecting transcription. Chromatin regulation involves the tightness of packing of DNA. When DNA is tightly packed, gene expression is slower.

==3D structures of CHD

2b2t – hCHD1 (mutant) + histone H3 tail – human
2b2u, 2b2v, 2b2w - hCHD1 + histone H3 tail
2b2y - hCHD1
2l5u – hCHD4 PHD finger 1 – NMR
2l75 - hCHD4 PHD finger 2 + histone H3 peptide – NMR
2ee1 – hCHD4 chromodomain – NMR
2epb – hCHD6 chromodomain 2 – NMR
2ckc, 2v0e, 2v0f – hCHD7 BRK domain - NMR
2dl6, 2cka – hCHD8 BRK domain - NMR

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Michal Harel, Alexander Berchansky

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