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Ketohexokinase

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Revision as of 11:08, 5 March 2012 by Michal Harel (Talk | contribs)
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Template:STRUCTURE 3nbv

Ketohexokinase (KHK) also known as hepatic fructokinase catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in the liver. The HKH gene is spliced to HKH-A and the more active HKH-C. HKH deficiency causes the essential fructosuria disorder. KHK acts in the first step of fructose metabolism.

3D structuresm of ketohexokinase

2hlz, 2hqq, 3b3l – hKHK – human
2hw1, 3nbv – hKHK + AMPPNP + fructose
3nbw – hKHK + pyrazole derivative
3nc2, 3nc9, 3nca, 3ro4, 3q92, 3qa2, 3qai – hKHK + inhibitor

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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