This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Interleukin receptor
From Proteopedia
Interleukin receptors (ILR) are cytokine receptor which are classified into type I, type II and . ILR type I are cell surface receptors which recognize cytokines with four α-helical strands. ILR type II are similar to typew I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses interleukin-1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A).
3D structures of interleukin receptor
Interleukin receptor type I
Interleukin-2 receptor
1z92 – hIL2R α subunit + interleukin-2
2b5i - hIL2R α+β+γ subunits + interleukin-2
2erj - hIL2R α (mutant)+β+γ (mutant) subunits + interleukin-2 (mutant)
3iu3, 3nfp - hIL2R α subunit + antibody
Interleukin-4 receptor
1iar - hIL4R α (mutant) subunit + interleukin-4
3bpl - hIL4R α + γ subunits + interleukin-4
3bpn - hIL4R α subunit + hIL13R α subunit + interleukin-4
3bpo - hIL4R α subunit + hIL13R α subunit + interleukin-13
Interleukin-5 receptor
3qt2 – hIL5R α (mutant) subunit + interleukin-5
Interleukin-6 receptor or gp130
1i1r – hIL6R β subunit + interleukin-6 homolog
1pvh - hIL6R β subunit + leukemia inhILbitory factor
2hmh - I6R β subunit + suppressor of cytokine signaling 3 – mouse
3l5i, 3l5j, 3l5h - hIL6R β subunit
1n26 - hIL6R α subunit
2arw - hIL6R α subunit - NMR
1p9m - hIL6R α + β subunits + interleukin-6
Interleukin-7 receptor
3up1 - hIL7R α subunit
3di2, 3di3 – hIL7R α (mutant) subunit + interleukin-7 (mutant)
Interleukin-13 receptor
3lb6 - hIL13R α2 (mutant) subunit + interleukin-13
Interleukin-15 receptor
2ers - hIL15R α subunit sushIL domain – NMR
2z3q, 2z3r, 2psm - hIL15R α subunit + interleukin-15
Interleukin-17 receptor
3jvf - hIL17RA extracellular domain + interleukin-17F
Interleukin-21 receptor
3tgx – hIL21R extracellular domain (mutant) + interleukin-21
Interleukin receptor type II
Interleukin-10 receptor
1j7v – hIL10R α (mutant) subunit + interleukin-10
1lqs, 1y6m, 1y6n - hIL10R α (mutant) subunit + interleukin-10 homolog
1y6k - hIL10R α (mutant) subunit + interleukin-10
3lqm - hIL10R β (mutant) subunit
Interleukin-22 receptor
3dgc – hIL22R α (mutant) subunit + interleukin-22
3dlq - hIL22R α (mutant) subunit + interleukin-2 (mutant)
Interleukin receptor of immunoglobulin family
Interleukin-1 receptor
1itb – hI1R1 extracellular domain + interleukin-1 β – human
1ira- hI1R1 extracellular domain + I1R1A
1g0y - hI1R1 extracellular domain + I1R1A peptide
3o4o - hI1R2 + interleukin-1 β
