Journal:JMB:2

From Proteopedia

Title Of The Paper

Authors^[1]

Molecular Tour
Figure  1.    General  mechanisms  for  the  hydrolysis  of  the  three  classes  of  rePON1  substrates:   the  lactones  (A),  the  esters  (B)  and  the  phosphotriesters  (C).  The  2HQ  inhibitor  and  additional   substrate  molecules  are  presented  (D).  

Figure  3.  Changes  in  the  rePON1  binding  site  upon  binding  of  2HQ.  Superimposition  of  the   rePON1-­2HQ  complex  (cyan;;  the  closed  conformation)  with  the  apo  rePON1  structures  at  pH   4.5  (orange)  and  pH  6.5  (blue)  (the  open  conformations).  The  pH  4.5  conformation  prevents   closure  of  the  active-­site  loop  due  to  clashes  of  F347  and  H348  with  the  loop  residues  (e.g.   F77  and  I74).  Also  illustrated  is  the  movement  of  Y71  (dashed  arrow)  upon  binding  of  2HQ,   and  its  interaction  with  D183  in  the  2HQ  complex  structure.

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