3ug2
From Proteopedia
Crystal structure of the mutated EGFR kinase domain (G719S/T790M) in complex with gefitinib
Template:ABSTRACT PUBMED 22349823
About this Structure
3ug2 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Yoshikawa S, Kukimoto-Niino M, Parker L, Handa N, Terada T, Fujimoto T, Terazawa Y, Wakiyama M, Sato M, Sano S, Kobayashi T, Tanaka T, Chen L, Liu ZJ, Wang BC, Shirouzu M, Kawa S, Semba K, Yamamoto T, Yokoyama S. Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor. Oncogene. 2012 Feb 20. doi: 10.1038/onc.2012.21. PMID:22349823 doi:10.1038/onc.2012.21
Categories: Homo sapiens | Receptor protein-tyrosine kinase | Handa, N. | Kukimoto-Niino, M. | Parker, L J. | Shirouzu, M. | Yokoyama, S. | Yoshikawa, S. | Atp binding | Cell cycle | Disease mutation | Drug resistance | Kinase | Phosphorylation | Receptor | Transferase-transferase inhibitor complex | Transmembrane | Tyrosine-protein kinase
