This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Pyruvate dehydrogenase kinase

From Proteopedia

Revision as of 09:20, 13 March 2012 by Michal Harel (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search

Pyruvate dehydrogenase kinase (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length]], [[activity and phosphorylation sites.

PDK isozyme 1

2q8f – hPDK1 – human
2q8g – hPDK1 + drug
2q8h – hPDK1 + dichloro-acetic acid

PDK isozyme 2

1jm6 – PDK2 + ADP – rat
2btz – hPDK2
2bu2 – hPDK2 + benzonitrile derivative + ATP
2bu5 - hPDK2 + benzonitrile derivative
2bu6 - hPDK2 + propanamide derivative
2bu7 - hPDK2 + acetamide derivative
2bu8 - hPDK2 + dichloro-acetic acid + ADP
3crk, 3crl – hPDK2 + acetyltransferase component of pyruvate dehydrogenase complex

PDK isozyme 3

1y8n, 1y8o, 1y8p, 2pnr – hPDK3 + acetyltransferase component of pyruvate dehydrogenase complex
2q8i – hPDK3 + radicicol

PDK isozyme 4

2e0a – hPDK4 + AMPPNP
2zkj, 3d2r – hPDK4 + ADP
2zdx, 2zdy – hPDK4 (mutant) + inhibitor

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Pyruvate_dehydrogenase_kinase"
Personal tools