1e8b
From Proteopedia
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SOLUTION STRUCTURE OF 6F11F22F2, A COMPACT THREE-MODULE FRAGMENT OF THE GELATIN-BINDING DOMAIN OF HUMAN FIBRONECTIN
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Overview
The solution structure of the (6)F1(1)F2(2)F2 fragment from the, gelatin-binding region of fibronectin has been determined (Protein Data, Bank entry codes 1e88 and 1e8b). The structure reveals an extensive, hydrophobic interface between the non-contiguous (6)F1 and (2)F2 modules., The buried surface area between (6)F1 and (2)F2 ( approximately 870 A(2)), is the largest intermodule interface seen in fibronectin to date. The, dissection of (6)F1(1)F2(2)F2 into the (6)F1(1)F2 pair and (2)F2 results, in near-complete loss of gelatin-binding activity. The hairpin topology of, (6)F1(1)F2(2)F2 may facilitate intramolecular contact between the matrix, assembly regions flanking the gelatin-binding domain. This is the first, high-resolution study to reveal a compact, globular arrangement of modules, in fibronectin. This arrangement is not consistent with the view that, fibronectin is simply a linear 'string of beads'.
Disease
Known diseases associated with this structure: Ehlers-Danlos syndrome, type X, 225310 (1) OMIM:[135600]
About this Structure
1E8B is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
The hairpin structure of the (6)F1(1)F2(2)F2 fragment from human fibronectin enhances gelatin binding., Pickford AR, Smith SP, Staunton D, Boyd J, Campbell ID, EMBO J. 2001 Apr 2;20(7):1519-29. PMID:11285216
Page seeded by OCA on Fri Feb 15 15:41:56 2008
