User:Olivia Cheng/Sandbox 1

From Proteopedia

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This is my sandbox!

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Lyme disease

OspB Fab with H6831

spinqualitylabelsall models 1RJL Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

1RJL

OspB consists of .

H6831 along with CB2 are a monoclonal antibodies.

Potential Catalytic Triad

spinqualitylabelsall models 1P4P Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

1P4P

There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases. This resemblance of the consist of -166, -162, and -184.

References

Becker, M. Structural Investigation of Borrelia burgodrei OspB, a BactericidalFab Target

Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections

Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis