User:Olivia Cheng/Sandbox 1
From Proteopedia
This is my sandbox!
Lyme disease
OspB Fab with H6831
|
1RJL
OspB consists of .
H6831 along with CB2 are a monoclonal antibodies.
Potential Catalytic Triad
|
1P4P
There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases. This resemblance of the serine protease catalytic triad consists of .
The trio may cause a self-proteolysis.
References
Becker, M. Structural Investigation of Borrelia burgodrei OspB, a BactericidalFab Target
Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections
Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis
