User:Olivia Cheng/Sandbox 1

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Lyme disease



OspB Fab with H6831

Model of 1RJL with Chain C in purple and Chains A, B, and D white

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OspB consists of .

H6831 along with CB2 are a monoclonal antibodies.






















Potential Catalytic Triad

1P4P

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1P4P


There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on Serine proteases. For more information on serine proteaseBecker, M. Structural Investigation of Borrelia burgodrei OspB, a BactericidalFab Targetelf-proteolysis.





References

Becker M, Bunikis J, Lade BD, Dunn JJ, Barbour AG, Lawson CL. Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab target. J Biol Chem. 2005 Apr 29;280(17):17363-70. Epub 2005 Feb 15. PMID:15713683 doi:10.1074/jbc.M412842200

Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections

Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis

Proteopedia Page Contributors and Editors (what is this?)

Olivia Cheng

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