User:Olivia Cheng/Sandbox 1

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--Olivia Cheng 23:30, 27 March 2012 (IST)This is my sandbox!

Outer Surface Protein B (OspB) is a component


Hemoglobin

OspB Interaction with Fab of H6831

1RJL with Chain C in purple and Chains A, B, and D white

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OspB consists of .

H6831 along with CB2 are a monoclonal antibodies.


H6831 appears to have a bactericidal effect on OspB in the absence of complement proteins.















Potential Catalytic Triad

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Proposed Mechanism



There are 3 residues that exist on the eliminated B-sheet of OspB that highly resemble the catalytic triad on [http://en.wikipedia.org/wiki/Serine_protease Serine proteasoccur.




References

Becker M, Bunikis J, Lade BD, Dunn JJ, Barbour AG, Lawson CL. Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab target. J Biol Chem. 2005 Apr 29;280(17):17363-70. Epub 2005 Feb 15. PMID:15713683 doi:10.1074/jbc.M412842200

Connolly, S. The Versatile Roles of Antibodies in Borrelia Infections

Katona, L. A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis

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Olivia Cheng

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