1i0e

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1i0e, resolution 3.50Å

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CRYSTAL STRUCTURE OF CREATINE KINASE FROM HUMAN MUSCLE

Overview

The crystal structure of human muscle creatine kinase has been determined, by the molecular-replacement method and refined at 3.5A resolution. The, structures of both the monomer and the dimer closely resemble those of the, other known structures in the creatine kinase family. Two types of dimers, one with a non-crystallographic twofold symmetry axis and the other with a, crystallographic twofold symmetry axis, were found to exist simultaneously, in the crystal. These dimers form an infinite "double-helix"-like, structure along an unusual long crystallographic 3(1) axis.

About this Structure

1I0E is a Single protein structure of sequence from Homo sapiens. Active as Creatine kinase, with EC number 2.7.3.2 Full crystallographic information is available from OCA.

Reference

Structure of human muscle creatine kinase., Shen YQ, Tang L, Zhou HM, Lin ZJ, Acta Crystallogr D Biol Crystallogr. 2001 Aug;57(Pt 8):1196-200. PMID:11517911

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