1iap

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Image:1iap.jpg

1iap, resolution 1.90Å

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CRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAIN

Contents

Overview

p115RhoGEF, a guanine nucleotide exchange factor for Rho GTPase, is also a, GTPase activating protein (GAP) for G(12) and G(13) heterotrimeric G alpha, subunits. Near its N-terminus, p115RhoGEF contains a domain (rgRGS) with, remote sequence identity to RGS (regulators of G protein signaling), domains. The rgRGS domain is necessary but not sufficient for the GAP, activity of p115RhoGEF. The 1.9 A resolution crystal structure of the, rgRGS domain shows structural similarity to RGS domains but possesses a, C-terminal extension that folds into a layer of helices that pack against, the hydrophobic core of the domain. Mutagenesis experiments show that, rgRGS may form interactions with G alpha(13) that are analogous to those, in complexes of RGS proteins with their G alpha substrates.

Disease

Known disease associated with this structure: Slowed nerve conduction velocity, AD OMIM:[608136]

About this Structure

1IAP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the rgRGS domain of p115RhoGEF., Chen Z, Wells CD, Sternweis PC, Sprang SR, Nat Struct Biol. 2001 Sep;8(9):805-9. PMID:11524686

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