1ip0
From Proteopedia
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NMR STRUCTURE OF HUMAN BETACELLULIN-2
Overview
The solution structure of the EGF-like domain of betacellulin (BTCe), a, newly discovered member of the epidermal growth factor (EGF) family, has, been determined using two-dimensional nuclear magnetic resonance, spectroscopy. This is the first report to identify the solution structure, of the EGF-family ligand monomers that interact with both ErbB-1 and, ErbB-4. The solution structure of BTCe was calculated using 538, NMR-derived restraints. The overall structure of BTCe was stabilized by, three disulfide bonds, a hydrophobic core, and 23 hydrogen bonds. It, appears that BTCe is comprised of five beta-strands and one short 3(10), helical turn. The secondary structural elements of BTCe are basically, similar to those of the other EGF-family proteins, except that several, significant variations of the structural properties were found. It is, suggested that the structural variations between BTCe and the other, EGF-family ligands may affect the specific receptor-recognition properties, of EGF-family ligands.
About this Structure
1IP0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of betacellulin, a new member of EGF-family ligands., Miura K, Doura H, Aizawa T, Tada H, Seno M, Yamada H, Kawano K, Biochem Biophys Res Commun. 2002 Jun 28;294(5):1040-6. PMID:12074582
Page seeded by OCA on Fri Feb 15 16:02:47 2008
Categories: Homo sapiens | Single protein | Aizawa, T. | Doura, H. | Kawano, K. | Miura, K. | Seno, M. | Tada, H. | Yamada, H. | Egf-like fold
