1iq3

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1iq3

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SOLUTION STRUCTURE OF THE EPS15 HOMOLOGY DOMAIN OF A HUMAN POB1

Overview

The solution structure of the Eps15 homology (EH) domain of a human POB1, (partner of RaIBP1) has been determined by uniform 13C/15N labeling and, heteronuclear multidimensional nuclear magnetic resonance spectroscopy., The POB1 EH domain consists of two EF-hand structures, and the second one, binds a calcium ion. In the calcium-bound state, the orientation of the, fourth alpha-helix relative to the other helices of the POB1 EH domain is, slightly different from that of calbindin, and much more different from, those of calmodulin and troponin C, on the basis of their atomic, coordinates.

About this Structure

1IQ3 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.

Reference

Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1)., Koshiba S, Kigawa T, Iwahara J, Kikuchi A, Yokoyama S, FEBS Lett. 1999 Jan 15;442(2-3):138-42. PMID:9928989

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