Phosphotriesterase

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Phosphotriesterase (PTE) catalyzes the conversion of aryl dialkyl phosphate to dialkyl phosphate and aryl alcohol. PTE has no known natural substrate but has potential in detoxification of organophosphates poisons lethal effects. PTE can detoxify the insecticide paraoxon and the chemical warfare agent sarin.

3D structure of phosphotriesterase

Phosphotriesterase complex with metal ion

1pta – BdPTE – Brevundimonas diminuta
1hzy - BdPTE + Zn
2ob3, 2o4m, 2o4q, 2oql - BdPTE (mutant) + Zn
3cs2 - BdPTE (mutant) + Co
1i0b - BdPTE + Mn
1i0d - BdPTE + Cd + Zn
1jgm - BdPTE + Cd
1p6b - FlPTE (mutant) + Zn – Flavobacterium
2d2j, 3a3x, 3a4j, 3oqe - AtPTE (mutant) + Co – Agrobacterium tumefaciens
2gvu - LvPTE (mutant) + Ca – Loligo vulgaris
2gvw - LvPTE + Ca
2zc1 - DrPTE + Co – Deinococcus radiodurans
3fdk - DrPTE + Zn
3gtf, 3gth, 3gti, 3gtx, 3gu1, 3gu2, 3gu9 - DrPTE (mutant) + Co
3htw - DrPTE + Mg + Co
3orw - GkPTE + Co – Geobacillus kaustophilus

Phosphotriesterase ternary complex with metal ion

1psc - BdPTE + substrate analog + Cd
1eyw, 1dpm, 1ez2 - BdPTE + substrate analog + Zn
3cak - BdPTE + product + Co
1qw7, 3e3h - BdPTE (mutant) + substrate analog + Co
1p6c - FlPTE (mutant) + substrate analog + Zn
2gvv - LvPTE + substrate analog + Ca
2d2g, 2r1k, 2r1l, 2r1m, 2r1p, 3c86 - AtPTE (mutant) + product + Co
2d2h - AtPTE (mutant) + inhibitor + Co
2r1n - AtPTE (mutant) + substrate + Co
3so7 - AtPTE + phosphate + Co
3a3w, 3ood - AtPTE (mutant) + substrate analog + Co
3ojg - GkPTE + lactone + Fe + Zn

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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