4alh

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Image:4alh.jpg

Template:STRUCTURE 4alh

N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 3,5 dimethyl-4-phenyl-1,2- oxazole

Template:ABSTRACT PUBMED 22136469

About this Structure

4alh is a 3 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 4a9p. Full crystallographic information is available from OCA.

Reference

  • Bamborough P, Diallo H, Goodacre JD, Gordon L, Lewis A, Seal JT, Wilson DM, Woodrow MD, Chung CW. Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides. J Med Chem. 2012 Jan 26;55(2):587-96. Epub 2012 Jan 11. PMID:22136469 doi:10.1021/jm201283q

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