3tki

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Image:3tki.jpg

Template:STRUCTURE 3tki

Crystal structure of Chk1 in complex with inhibitor S25

Template:ABSTRACT PUBMED 22374217

About this Structure

3tki is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Dudkin VY, Rickert K, Kreatsoulas C, Wang C, Arrington KL, Fraley ME, Hartman GD, Yan Y, Ikuta M, Stirdivant SM, Drakas RA, Walsh ES, Hamilton K, Buser CA, Lobell RB, Sepp-Lorenzino L. Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2609-12. Epub 2012 Feb 9. PMID:22374217 doi:10.1016/j.bmcl.2012.01.110

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