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4dwv

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Image:4dwv.jpg

Template:STRUCTURE 4dwv

Horse alcohol dehydrogenase complexed with NAD+ and 2,3,4,5,6-pentafluorobenzyl alcohol

Template:ABSTRACT PUBMED 8172897

About this Structure

4dwv is a 2 chain structure with sequence from Equus caballus. Full crystallographic information is available from OCA.

Reference

  • Ramaswamy S, Eklund H, Plapp BV. Structures of horse liver alcohol dehydrogenase complexed with NAD+ and substituted benzyl alcohols. Biochemistry. 1994 May 3;33(17):5230-7. PMID:8172897
  • Rubach JK, Plapp BV. Amino acid residues in the nicotinamide binding site contribute to catalysis by horse liver alcohol dehydrogenase. Biochemistry. 2003 Mar 18;42(10):2907-15. PMID:12627956 doi:10.1021/bi0272656
  • Venkataramaiah TH, Plapp BV. Formamides mimic aldehydes and inhibit liver alcohol dehydrogenases and ethanol metabolism. J Biol Chem. 2003 Sep 19;278(38):36699-706. Epub 2003 Jul 10. PMID:12855684 doi:10.1074/jbc.M305419200

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