2bj4
From Proteopedia
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ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH A PHAGE-DISPLAY DERIVED PEPTIDE ANTAGONIST
Overview
Recent studies have identified a series of estrogen receptor, (ER)-interacting peptides that recognize sites that are distinct from the, classic coregulator recruitment (AF2) region. Here, we report the, structural and functional characterization of an ERalpha-specific peptide, that binds to the liganded receptor in an AF2-independent manner. The 2-A, crystal structure of the ER/peptide complex reveals a binding site that is, centered on a shallow depression on the beta-hairpin face of the, ligand-binding domain. The peptide binds in an unusual extended, conformation and makes multiple contacts with the ligand-binding domain., The location and architecture of the binding site provides an insight into, the peptide's ER subtype specificity and ligand interaction preferences., In vivo, an ... [(full description)]
About this Structure
2BJ4 is a [Single protein] structure of sequence from [Homo sapiens] with OHT as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Delineation of a unique protein-protein interaction site on the surface of the estrogen receptor., Kong EH, Heldring N, Gustafsson JA, Treuter E, Hubbard RE, Pike AC, Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3593-8. Epub 2005 Feb 23. PMID:15728727
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