Sandbox Reserved 481

• Click the edit this page tab at the top. Save the page after each step, then edit it again.
• Click the 3D button (when editing, above the wikitext box) to insert Jmol.
• show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
• Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

For more help, look at this link: http://www.proteopedia.org/wiki/index.php/Help:Getting_Started_in_Proteopedia

Introduction

Cholix toxin are a class of protein toxin originating from the bacteria Vibrio Cholerae. The toxin uses ADP-riboyltransferase to inactivate eukaryotic elongation factor 2 by transferring ADP-ribose from NAD+ which inhibits protein synthesis and causes cell death. This protein toxin has been known to cause disease in both plants and animals. Specifically, the toxin can cause the disease Cholera. It enters eukaryotic cells through cell mediated endocytosis. Once inside, the toxin transfers an ADP-ribose group to an Arg residue of the GTP binding protein G. This then activates adenylate cyclase which leads to an increase amount of cAMP, causing a secretion of Cl-,HCO3-, and water from epithelial cells from the site of colonization. The result is dehydration and loss of electrolytes in mammals. Cholix toxins are composed of a receptor binding, translocation, and catalytic domain.

Structure

Mechanism of Action

Medical Implications or Possible Applications

References

1. The 1.8A Cholix Toxin Crystal Structure in Complex with NAD+ and Evidence for a New Kinetic Model