Formate dehydrogenase

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Template:STRUCTURE 2nad Formate dehydrogenase (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate. The product electron is donated to either NAD+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe4S4 center and then to cytochrome. The Mo-dependent FDH-H from E. coli contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe4S4.

3D structure of formate dehydrogenase

NAD-dependent FDH

2nac, 2go1 – PsFDH – Pseudomonas
2fss – CbFDH – Candida boidinii
2j6i – CbFDH C terminal (mutant)
3fn4 - MoFDH – Moraxella
3naq, 3jtm – ArFDH – Arabidopsis thaliana
2nad – PsFDH + NAD
2gug – PsFDH + formate
2gsd – MoFDH + NAD + N3
3n7u - ArFDH + NAD + N3

Mo-dependent FDH

1aa6, 1fdo, 2iv2 – EcFDH-H + Fe4S4 + MGD – Escherichia coli
1fdi - EcFDH-H + Fe4S4 + NO2 + MGD
1kqf - EcFDH-N + Fe4S4 + protoporphyrin + MGD
1kqg - EcFDH-N + Fe4S4 + protoporphyrin + heptyl-oxy-quinolinol + MGD
1h0h - FDH + Fe4S4 +MGD – Desulfovibrio gigas

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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