1r55
From Proteopedia
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Crystal structure of the catalytic domain of human ADAM 33
Overview
Adam33 is a putative asthma susceptibility gene encoding for a, membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs, (a disintegrin and metalloprotease) are a family of glycoproteins, implicated in cell-cell interactions, cell fusion, and cell signaling. We, have determined the crystal structure of the Adam33 catalytic domain in, complex with the inhibitor marimastat and the inhibitor-free form. The, structures reveal the polypeptide fold and active site environment, resembling that of other metalloproteases. The substrate-binding site, contains unique features that allow the structure-based design of specific, inhibitors of this enzyme.
About this Structure
1R55 is a Single protein structure of sequence from Homo sapiens with , , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the catalytic domain of human ADAM33., Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V, J Mol Biol. 2004 Jan 2;335(1):129-37. PMID:14659745
Page seeded by OCA on Fri Feb 15 16:47:00 2008
Categories: Homo sapiens | Single protein | Hammond, G. | Le, H.V. | Madison, V. | Mirza, U.A. | Orth, P. | Prosise, W.W. | Reichert, P. | Strickland, C. | Taremi, S.S. | Wang, W. | Xiao, L. | Yarosh-Tomaine, T. | Zou, J. | 097 | CA | CL | ZN | Adam | Asthma | Inhibitor | Metalloprotease
