User:Jing Liu/Sandbox 1

From Proteopedia

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One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.

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This is a , which contains an in it.

Contents 1 DnaA function in Prokaryotes 2 Process of DNA Replication Initiation 3 DnaA Monomer Structure 4 Distinct Assembly State of DnaA 5 Reference

DnaA function in Prokaryotes

DnaA is an AAA+ protein in prokaryotes for DNA replication initiation. To ensure correct timing of DNA replication, intracellular DnaA is under multi-level control, including changing expression/degradation level, regulator control and functional activation/inactivation by nucleotide-depedent conformational change. DnaA is a conserved protein in prokaryotes. In E. coli, There are four regions in this protein:

I: residues 1-85. DnaB loading domain; II: residues 86-133. linker region; III: residues 134-372. ATPase domain; IV: residues 373-467. DNA binding domain;

Process of DNA Replication Initiation

DnaA Monomer Structure

Distinct Assembly State of DnaA

Reference