1uk0

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Image:1uk0.gif

1uk0, resolution 3.Å

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Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor

Contents

Overview

The crystal structure of human recombinant poly(ADP-ribose) polymerase, (PARP) complexed with a potent inhibitor, FR257517, was solved at 3.0 A, resolution. The fluorophenyl part of the inhibitor induces an amazing, conformational change in the active site of PARP by motion of the side, chain of the amino acid, Arg878, which forms the bottom of the active, site. Consequently, a corn-shaped hydrophobic subsite, which consists of, the side chains of Leu769, Ile879, Pro881, and the methylene chain of, Arg878, newly emerges from the well-known active site.

Disease

Known diseases associated with this structure: Xeroderma pigmentosum (1) OMIM:[173870]

About this Structure

1UK0 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as NAD(+) ADP-ribosyltransferase, with EC number 2.4.2.30 Full crystallographic information is available from OCA.

Reference

Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase., Kinoshita T, Nakanishi I, Warizaya M, Iwashita A, Kido Y, Hattori K, Fujii T, FEBS Lett. 2004 Jan 2;556(1-3):43-6. PMID:14706823

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