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1ukl

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Image:1ukl.jpg

1ukl, resolution 3.00Å

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Crystal structure of Importin-beta and SREBP-2 complex

Overview

The sterol regulatory element-binding protein 2 (SREBP-2), a nuclear, transcription factor that is essential for cholesterol metabolism, enters, the nucleus through a direct interaction of its helix-loop-helix leucine, zipper domain with importin-beta. We show the crystal structure of, importin-beta complexed with the active form of SREBP-2. Importin-beta, uses characteristic long helices like a pair of chopsticks to interact, with an SREBP-2 dimer. Importin-beta changes its conformation to reveal a, pseudo-twofold symmetry on its surface structure so that it can, accommodate a symmetric dimer molecule. Importin-beta may use a similar, strategy to recognize other dimeric cargoes.

About this Structure

1UKL is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor., Lee SJ, Sekimoto T, Yamashita E, Nagoshi E, Nakagawa A, Imamoto N, Yoshimura M, Sakai H, Chong KT, Tsukihara T, Yoneda Y, Science. 2003 Nov 28;302(5650):1571-5. PMID:14645851

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