1ytf

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Image:1ytf.jpg

1ytf, resolution 2.500Å

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YEAST TFIIA/TBP/DNA COMPLEX

Overview

The X-ray crystal structure of the transcription factor IIA (TFIIA) in, complex with the TATA-box-binding protein (TBP) and TATA-element DNA is, presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a, four-helix bundle motif that together have a boot-like appearance. The, beta-barrel extends the TBP beta-sheet and bridges over the DNA major, groove immediately upstream of the TATA box. The four-helix bundle, contributes substantially to the surface of the complex available for, interaction with additional transcription factors.

About this Structure

1YTF is a Protein complex structure of sequences from Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1YTF with [TATA-Binding Protein]. Full crystallographic information is available from OCA.

Reference

Crystal structure of a yeast TFIIA/TBP/DNA complex., Tan S, Hunziker Y, Sargent DF, Richmond TJ, Nature. 1996 May 9;381(6578):127-51. PMID:8610010

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