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2wd8

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Image:2wd8.png

Template:STRUCTURE 2wd8

PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00071204

Template:ABSTRACT PUBMED 19527033

About this Structure

2wd8 is a 4 chain structure with sequence from Trypanosoma brucei brucei. Full crystallographic information is available from OCA.

Reference

  • Mpamhanga CP, Spinks D, Tulloch LB, Shanks EJ, Robinson DA, Collie IT, Fairlamb AH, Wyatt PG, Frearson JA, Hunter WN, Gilbert IH, Brenk R. One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening. J Med Chem. 2009 Jun 15. PMID:19527033 doi:10.1021/jm900414x
  • Dawson A, Gibellini F, Sienkiewicz N, Tulloch LB, Fyfe PK, McLuskey K, Fairlamb AH, Hunter WN. Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate. Mol Microbiol. 2006 Sep;61(6):1457-68. PMID:16968221 doi:10.1111/j.1365-2958.2006.05332.x

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