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3gw9

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Image:3gw9.png

Template:STRUCTURE 3gw9

Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei bound to an inhibitor N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxaziazol-2-yl)benzamide

Template:ABSTRACT PUBMED 19923211

About this Structure

3gw9 is a 4 chain structure with sequence from Trypanosoma brucei. Full crystallographic information is available from OCA.

Reference

  • Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR. Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. J Biol Chem. 2010 Jan 15;285(3):1773-80. Epub 2009 Nov 18. PMID:19923211 doi:M109.067470

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